Endocrine Abstracts

The Na+/I- symporter (NIS) is an intrinsic plasma membrane glycoprotein that mediates active I- transport in the thyroid follicular cells, the first step in thyroid hormone biosynthesis. Na+/I- symport occurs with a two Na+ per one I- stoichiometry. Endogenous functional expression of NIS in thyroid cancer is the foundation for the single most effective and most side effect-free anti-cancerous targete...

Nancy Carrasco, Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, NY, USA AbstractDr. Nancy Carrasco was born in Mexico City. She obtained her Medical Doctor and Masters in Biochemistry degrees from the National Autonomous University of Mexico. Dr. Carrasco was a postdoctoral fellow in the laboratory of Dr. Kaback at the Roche Institute of Molecular Biology in New Jersey, U.S.A., wher...

We determined in vitro activity of 17β-estradiol and or progesterone on glutamate conversion to GABA in different GABAergic regions from the brain of castrated and non-castrated rats. The glutamate decarboxylase catalyzes this conversion; there are two different isotypes of glutamate decarboxylase, GAD65 and GAD67. Whereas GAD65 is a membrane enzyme, GAD67 is present in the supernatant obtained after centrifuging to 14,...

Sleep is disturbed in both healthy and pathological aging, so it is essential to consider the role of ovarian hormones in both processes. Studies supporting the natural function of E2 (or elevated FSH) in fragmented sleep are inconsistent because when non-human animals have been used, they have mainly been male. Given this background, this study focused on determining the role of different estradiol and progesterone doses in the intermittent arousals of castrated rats maintain...

The Na+/I- symporter (NIS) is a plasma membrane glycoprotein that mediates active I- transport in the thyroid follicular cells (the first step in thyroid hormone biosynthesis), and in other tissues, such as lactating mammary gland. NIS is the basis for the effective use of radioiodide in the diagnostic and treatment of thyroid cancer. NIS mutations hae been identified as causes of congenital iodide transport defect (ITD). We have isolated the cDNA that encodes NIS, generated h...

The Na+/I− symporter (NIS) is a key plasma membrane protein that mediates active I− uptake in the thyroid, lactating breast, and other tissues with an electrogenic stoichiometry of 2 Na+ per I−. In the thyroid, NIS-mediated I− uptake is the first step in the biosynthesis of the iodine-containing thyroid hormones, which are essential early in life for proper development of the central nerv...

Introduction: Gestational diabetes (GD) is one of the most common complications of pregnancy. Thyroid hormones play an important role in carbohydrate homeostasis, however, their influence on the risk of developing gestational diabetes has shown contradictory results.Objective: To explore whether variations in thyroid function parameters, within the thresholds of normality, can be associated with the risk of developing GD.Material a...

Objective: We will analyze various characteristics of the patients who attend the HUMV Diabetic Foot Unit for a week. The variables studied are sex, age, type of diabetes, years of evolution, type of current treatment, last glycosylated hemoglobin, presence of other cardiovascular risk factors and existence of previous ulcerations and amputationsMaterial and Methods: We worked with Microsoft Excel to coollect the data and perform the statistical study.</...

Introduction Angiopoietin-like 4 protein (ANGPTL-4) is importantly produced in adipose tissue, mediates the inhibition of lipoprotein-lipase and has been recently related with the risk of atherosclerosis and type 2 diabetes (T2D). Bariatric surgery has demonstrated improvements in lipid profile, T2D and cardiovascular risk. But information about ANGPTL-4 circulating levels in severe obesity and after bariatric surgery is scarce.Obj...